Recent publications do not only contribute to the question of efficacy and safety of application of isoflavones, but also to the choice of a safe and efficacious daily dose. These questions were the focus of a recent clinical perspective paper of Dr. Bernd Kleine-Gunk, member of the Isoflavone Research Initiative.
Dr. Kleine-Gunk concludes that - compared with placebo - the efficacy of isoflavones against menopausal complaints is by now well-established with a daily intake above 50 mg. Similarly, safety at hormone-sensitive tissues can by now be accepted as given up to doses by far exceeding 100 mg per day.
Reference:
Bernd Kleine-Gunk: Neue Studiendaten stützen Phytotherapie als HRT-Alternative. gynäkologie + Geburtshilfe (12): 16-17 (2010)
The full text (in German) is available at www.gynundgeburtshilfe.de
